Restricted diffusion in skeletal muscle capillaries in man.
نویسندگان
چکیده
TRAP-JENSEN, JENS, AND NIELS A. LASSEN. Restricted d@xsion in skeletal muscle capillaries in man. Am. J. Physiol. 220(2) : 371-376. 197 1 .-The skeletal muscle capillary permeabilities for EDTA51Cr and inulin were measured simultaneously by means of the indicator-diffusion technique in the exercising forearm of nine normal human adults. The capillary permeability data were expressed as the capillary diffusion capacity, CDC, defined as the unidirectional flux of permeable tracer across the capillary membrane per 100 g tissue per unit concentration difference across the capillary. The average values for CDCnnTA-cr and CDCinulin amounted to 3.26 =t 0.74 (SD) and 0.51 =t 0.16 (SD) moles/l00 g emin per mole/ml, respectively, for plasma flows of 14.1 * 6.8 (SD) ml/100 g* min. The ratio between the mean CDC values EDTA-51Cr/inulin was found to be 6.39 =t 0.64 (SEM). This value highly exceeds the ratio value of 3.2 between the corresponding free-diffusion constants in water. The finding indicates the existence of restriction to diffusion for smaller hydrophilic molecules over the skeletal muscle capillary membrane. The finding is in accordance with the morphological observations of apertures with a narrowest diameter of ca. 40 A situated between the skeletal muscle capillary endothelial cells.
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عنوان ژورنال:
- The American journal of physiology
دوره 220 2 شماره
صفحات -
تاریخ انتشار 1971